Parkinson's Disease: Return of an Old Prime Suspect
نویسندگان
چکیده
Pacemaking activity in adult substantia nigra (SN) dopamine neurons relies on L-type Ca2+ channels, but a surprising study in Nature by Chan et al. demonstrates that blockade of these channels by dihydropyridines re-establishes the pacemaking driven by sodium and HCN channels found in juvenile SN. This shift protects SN neurons in chemical models of Parkinson's disease (PD), suggesting that elevated intracellular Ca2+ participates in SN cell loss and that dihydropyridines may provide therapy in PD.
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ورودعنوان ژورنال:
- Neuron
دوره 55 شماره
صفحات -
تاریخ انتشار 2007